Bioavailable
Zinc and Copper Complex*
HOW PATIENTS MAY BENEFIT
- For immune, skin, and male reproductive
health*
PRODUCT DISCUSSION
PhysioLogics Zinc Plex® provides Zinc, an essential trace element required for
numerous metabolic pathways. This formula also provides copper for additional
benefits.
STRUCTURE AND FUNCTION
Zinc is a ubiquitous trace element in the human body, acting as a cofactor for
more than 300 enzymes. DNA synthesis, RNA transcription, cell division, protein
synthesis and digestion are all dependent on the presence of Zinc. The DNA
structural motif known as a Zinc finger is a site of transcriptional regulation,
with Zinc-binding proteins involved in the genetic expression of various
biological compounds.
Zinc metalloenzymes catalyze approximately 50
important biochemical reactions and are a part of all classes of enzymes,
including oxidoreductases, transferases, hydrolases, lyases, isomerases, and
ligases. They can function catalytically by the binding of the substrate
directly to Zinc or a Zinc-hydroxide ion, or structurally, with Zinc stabilizing
the quaternary structure of oligomeric holoenzymes.
The precise mechanism of how Zinc affects male
reproductive health is not completely understood. Zinc is required for
spermatogenesis and aids in the formation of male sex hormone by Leydig cells.
The androgen receptor gene also contains a Zinc finger domain, necessary for the
development of male external genitalia.*
Zinc is known to play a central role in the
immune system. As a component of collagenase, Zinc contributes to healthy skin.
Zinc is essential for cell division, assisting rapidly dividing immune cells to
support the requirements of the immune system. In addition, Zinc assists in a
wide range of specific immune functions, including Immunoglobulin G (IgG)
production in B cells and IL-2 production in CD4+ T cells.*
CLINICAL EVIDENCE
- In a recent double blind human study, subjects
were given 45mg zinc/day for a period of 12 months. Subjects in the treated
group had significantly better immune function and low oxidative stress as
compared to the placebo group. (Prasad et al, 2007)
- 20 subjects received 10 mg of zinc aspartate
per day for about 48 days. Plasma zinc status and markers of protein
oxidation in lymphocytes were measured before and after the trial. Zinc
supplementation significantly reduced oxidative stress in cellular proteins
by maintaining the expression of protective enzymes. The results of this
study demonstrate the role of zinc as an antioxidant within the body. (Cabreiro
et al, 2008)
SUMMARY
PhysioLogics’ Zinc Plex® 30 mg provides a convenient way to support the immune
system and overall health with bioavailable forms of zinc supplemented with
copper for additional support.*
SUGGESTED DOSAGE
For adults, take one (1) capsule daily with meals, or follow the advice of a
health care professional. Do not exceed one (1) capsule per day.
REFERENCES
Cabreiro F, Perichon M, Jatje J, et al. Zinc supplementation in the elderly
subjects: Effect on oxidized protein degradation and repair systems in
peripheral blood lymphocytes. Exp Gerontol. 2008;43:483-7. Epub 2007 Oct 25
Eby GA, Davis DR, Halcomb WW. Reduction in
duration of common colds by zinc gluconate lozenges in a double-blind study.
Antimicrob Agents Chemother. 1984;25:20-4
Mahajan SK, Abbasi AA, Prasad AS, et al. Effect
of oral zinc therapy on gonadal function in hemodialysis patients. A
double-blind study. Ann Intern Med. 1982;97:357-61
Prasad, A. Zinc: An overview. Nutrition.
1995;11(1 Suppl):93-9
Prasad AS, Beck FW, Bao B, et al. Zinc
supplementation decreases incidence of infections in the elderly: effect of
zinc on generation of cytokines and oxidative stress. Am J Clin Nutr.
2007;85:837-44
Sherman AR. Zinc, copper, and iron nutriture
and immunity. J Nutr. 1992;122(3 Suppl):604-9
Turner RB, Cetnarowski WE. Effect of treatment
with zinc gluconate or zinc acetate on experimental and natural colds. Clin
Infect Dis. 2000;31:1202-8. Epub 2000 Nov 06
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